Cardiovascular adverse effects during itraconazole therapy

Cardiovascular adverse effects during itraconazole therapy.

Itraconazole has been widely used in the treatment of fungal disease including chronic necrotising pulmonary aspergillosis (CNPA) [1, 2]. Its use has been associated with occasional reports of adverse cardiovascular events including congestive heart failure [3], hypertension (HT) [4], premature ventricular contractions [5] and even ventricular fibrillation [6]. However, these adverse effects ha...

Adrenal response to corticotropin during therapy with itraconazole.

Itraconazole is a triazole with a mechanism of action similar to that of ketoconazole. Endocrine side effects of ketoconazole, including impaired cortisol synthesis, have been well documented (A. Pont, J. R. Graybill, P. C. Craven, J. N. Galgiani, W. E. Dismukes, R. E. Reitz, and D. A. Stevens, Arch. Intern. Med. 144:2150-2153, 1984). We examined the adrenal response to corticotropin in 10 pati...

Cardiovascular adverse effects of doping in sports.

Cardiovascular adverse effects of anti-inflammatory drugs.

Anti-inflammatory drugs consist of non-steroidal anti-inflammatory drugs (NSAIDs) including non-selective nsNSAIDs, aspirin, and cyclooxygenase-2 (COX-2)-selective inhibitors also referred to as coxibs, and glucocorticoids (GCs). They are worldwide prescribed drugs for many musculoskeletal conditions, such as osteoarthritis and inflammatory rheumatic diseases. Anti-inflammatory drugs can exert ...

The Adverse Effects of Nicotine and Carbon Monoxide on Cardiovascular Disease

Cigarette smoking causes injury of coronary arteries as well as other arteries. Sudden death is more frequent in heavy smokers than in non smok­ers. Studies showed that dangerous arrhythmias will be the result of effect of nicotine when injected in the animals. Carbon-monooxide is also dangerous for man when it is produced by smoking.  The prevention of heart disease will be more satisfactory ...